Nmr Research Papers

Medical practitioners employ magnetic resonance imaging (MRI), a multidimensional NMR imaging technique, for diagnostic purposes.

In 1945 two groups of physicists, one at Stanford, the other at Harvard, first reported the detection of NMR signals in condensed matter.

Research lines presently actives at the NMR Lab: - Molecular basis of Friedreich Ataxia disease - Search for biomarkers of cardiovascular risk - Development of a Serum NMR platform for HTS metabolomics studies of population.

Assessment of environmental risk and profilaxis - Characterization of the Mechanism of Action of anti-Schistosomiasi drugs - Development of new methods for drug discovery using NMR spectroscopy - Plasma Protein Binding of drug candidates using NMR - Characterization of therapeutic peptides - Study of the lipid profile of bone marrow in osteoporotic patients - Metabolomics applied to sport - Development of new compounds for the prevention of oxidative stress - Metabolomics characterization of bladder cancer - Search for enzymes working at low temperature in Antarctic’s organisms Collaborations: Departments at University of Rome “Tor Vergata” - Chemical Science and Technology - Experimental Medicine and Biochemical Science - Internal Medicine - Clinic Biochemistry - Policlinico Tor Vergata Italian Institutions and Companies - Centro Nazionale Composti Chimici e Screening, (CNCCS), consorzio pubblico privato CNR-ISS-IRBM - IRBM Science Park, Pomezia - Università di Roma “La Sapienza” - Policlinico Umberto I, Roma - Istituto di Biologia Cellulare, CNR - Istituto dei Sistemi Complessi, CNR - Facoltà di Medicina e Chirurgia, Università Vita-Salute San Raffaele, Milano - Ministero dell’Istruzione, dell’Università e della Ricerca, Programma Nazionale di Ricerche in Antartide - Bridgestone - Istituto Superiore di Sanità - Consorzio C4T International Institutions: - Università di Buenos Aires, Argentina - Istituto Fundación Leloir, Buenos Aires, Argentina - Instituto Antártico Argentino - Centro di Ingeniería Genética y Biotecnología (CIGB), l’Avana, Cuba Research Contracts (last five years): Research Contracts with CNCCS Consortium (Collezione Nazionale di Composti Chimici e Centro Screening): - “NMR Screening to select and improve potential therapeutic compounds for the treatment of Freidreich’s Ataxia”.

/ - “Screening via NMR di proteine contenenti poli-Q per la scoperta di agenti terapeutici per le malattie neurodegenerative”. / - “Sviluppo di nuovi agenti anti-Schistosomiasi”.

/ National and International Research Grants (last five years) “Search, characterization and evaluation of the biotechnological potential of enzymes active at low temperature from Antarctic organisms” PID-2011-006.

Coverage includes: Three-dimensional structure determination of biological macromolecules (polypeptides/proteins, DNA, RNA, oligosaccharides) by NMR; New NMR techniques for studies of biological macromolecules; Novel approaches to computer-aided automated analysis of multidimensional NMR spectra; Computational methods for the structural interpretation of NMR data, including structure refinement; Comparisons of structures determined by NMR with those obtained by other methods, e.g.

by diffraction techniques with protein single crystals; New techniques of sample preparation for NMR experiments, such as biosynthetic and chemical methods for isotope labeling, preparation of nutrients for biosynthetic isotope labeling.

Back to Top In 1948 two brothers, Russell and Sigurd Varian, armed with ,000, founded Varian Associates to manufacture scientific instruments.

According to a company history, the Varian brothers “intentionally settled near Stanford in order to enjoy the benefits of interchange with the various scientific programs in progress at the University.” Russell Varian in particular had a long association with Stanford; he had done his undergraduate and graduate work at the Palo Alto institution.

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