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These findings indicate that therapies targeting pancreatic cancer stromal components may have unintended mitogenic effects and that these effects can be reversed when imatinib is used in conjunction with radioimmunotherapy.
Full article Pancreatic cancer is a devastating disease.
Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates [...] Read more. It is the fourth leading cause of cancer-related death in Germany.
Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates of 25% and less than 5%, respectively, regardless of the stage at diagnosis.
Mice were injected with different concentrations of AC by local or systemic administration.
Changes in tumor progression were assessed by tumor size.
It is the fourth leading cause of cancer-related death in Germany.
The incidence in 2003/2004 was 16 cases per 100.000 inhabitants.
In this review, the most common neoadjuvant strategies will be described, compared and discussed. The expression of the tumor-associated antigen MUC-1 and the u PA receptor on three pancreatic cancer cell lines is reported for cell clusters, human mouse xenografts and lymph node metastases, as well as for human pancreatic cancer tissues, using immuno-histochemistry, confocal microscopy and flow cytometry.
The targeting vectors C595 and PAI2 were labeled with the alpha emitting radioisotope , the anti-proliferative effect for tumors was tested at two days post-subcutaneous cell inoculation.